Assessing gastrointestinal resistance, intestinal absorption and functionality of bioactive compounds as well as their ability to modulate the gut microbiota. These are all essential steps in the development of functional foods. The integrated system of the in vitro Dynamic Digester and cellular models allows us to study the gastrointestinal resistance of compounds contained in food, their intestinal absorption and their functional effect on target organs.
- DYNAMIC COLONIC FERMENTATION DIGESTER
Composed of five compartments: stomach, small intestine, and the three sections of the large intestine (ascending, transverse and descending colon). Similar to the previous one, it is computer-controlled and each compartment is subjected to the particular conditions of pH, enzyme secretion, etc. that apply to it. These trials last 1 month (7-11 days for the stabilisation of the microbiota with which we inoculate, and about 3 weeks for the trial itself), where we mainly study:
- Changes in the gut microbiota, both at the level of viable microorganisms (classical microbiological counts) and at the level of metagenomics
- Generation of specific secondary metabolites
- Metabolomic studies (We outsource these)